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BME Seminar: Juergen Hahn, Ph.D., BME Department Head, RPI

September 24, 11:00 am - 12:00 pm

On Friday, September 24th @ 11:00AM ET, we welcome BME Department Head Juergen Hahn from Rensselaer Polytechnic Institute as he presents, “Towards the Development of a Diagnostic Test for Autism Spectrum Disorder: Data Science Meets Metabolomics.”


Towards the Development of a Diagnostic Test for Autism Spectrum Disorder: Data Science Meets Metabolomics

Autism Spectrum Disorders (ASD) are a group of neurological disorders that present with limited social communication/interaction and restricted, repetitive behaviors/interests. The current estimate is that approximately 1.9% of children in the US are diagnosed with ASD. While this is a high prevalence and the economic burden by ASD is significant, there is still considerable debate regarding the underlying pathophysiology of ASD. Because of this lack of biological knowledge, autism diagnoses are restricted to observational behavioral and psychometric tools.

This work takes a step towards the goal of incorporating biochemical data into ASD diagnosis by analyzing measurements of metabolite concentrations of the folate-dependent one-carbon metabolism and transulfuration pathways. Unlike traditional approaches that are based upon comparing differences in individual metabolite concentrations between children with and without an ASD diagnosis, we made use of multivariate classification via Fisher Discriminant Analysis and used Kernel Partial Least Squares regression to predict adaptive behavior. The resulting levels of accuracy for classification as well as adaptive behavior prediction exceed any other approach in this field.



Juergen Hahn, Ph.D.Head of the Department of Biomedical Engineering at Rensselaer Polytechnic Institute

Juergen Hahn is head of the Department of Biomedical Engineering at Rensselaer Polytechnic Institute and holds an appointment in the Department of Chemical & Biological Engineering. His research interests include systems biology and process modeling and analysis with over 140 peer-reviewed publications in print. Dr. Hahn has received several awards and was elected as an AIMBE Fellow in 2013 and an AIChE Fellow in 2020. He served on the IEEE CSS Board of Governors in 2016 and has been a CACHE Trustee since 2014. He is currently serving as deputy editor-in-chief for the Journal of Process Control, as editor for the journal Optimal Control: Applications and Methods, and as associate editor for the journals Control Engineering Practice and the Journal of Advanced Manufacturing and Processing.



The Department of Biomedical Engineering at Columbia University is proud to host an annual weekly seminar series on the latest developments and research in Biomedical Engineering. The weekly series takes place on Friday mornings at 11:00AM Eastern and includes a variety of renowned academics from top universities to talk about their specific research and experience.

Click the link above for more info and to register!

Event Contact Information:
Alexis Newman