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BME WEBINAR SERIES: Gang Bao, PhD, BIOE Chair, Rice University

March 12, 11:00 am - 12:00 pm

On Friday, March 12th @ 11:00AM EST, we welcome Foyt Family Professor and Chair of the Department of Bioengineering at Rice University, Gang Bao, as he presents, “Genome editing based approaches for treating human diseases.”

ABOUT THE WEBINAR

Genome editing using engineered nucleases such as CRISPR/Cas9 systems is revolutionizing life sciences and medicine. It provides unprecedented opportunities for treating many genetic disorders.  However, significant challenges exist in order to treat a disease with high efficacy and safety using genome editing.  In this talk I will first focus on the development of a CRISPR/Cas9 based genome editing approach to treat sickle cell disease (SCD), which is a monogenic disorder that affects millions worldwide. We have systematically optimized the CRISPR gRNA and ssODN donor template designs, and achieved high gene editing rates in CD34+ HSPCs from patients with SCD. We have also performed extensive off-target analysis of gene-edited HSPCs and demonstrated the clinically relevant levels of engraftment in immunodeficient mice. I will then illustrate the importance of analyzing gene editing outcomes at the on-target Cas9 cut-site and their biological implications. Finally, I will describe a unique delivery vehicle for in vivo genome editing by combining magnetic nanoparticles (MNP) with baculoviral (BV) vector, and discuss the challenges and opportunities of in vivo genome editing.

ABOUT THE SPEAKER

Dr. Gang Bao is the Foyt Family Professor and Chair of the Department of Bioengineering, Rice University. Dr. Bao received his undergraduate and Master’s degrees from Shandong University in China, and his PhD from Lehigh University in the US. Dr. Bao is a Fellow of the American Association of Advancement in Science (AAAS), American Society of Mechanical Engineers (ASME), American Physical Society (APS), American Institute for Medical and Biological Engineering (AIMBE), and Biomedical Engineering Society (BMES). Dr. Bao’s current research is focused on the development of nanotechnology and biomolecular engineering tools for biological and disease studies, including CRISPR/Cas9 based genome editing for  treating single-gene disorders.

ABOUT THE 2020-2021 BME WEBINAR SERIES

The Department of Biomedical Engineering at Columbia University is proud to host an annual weekly webinar series on the latest developments and research in Biomedical Engineering. The weekly series takes place on Friday mornings at 11:00AM Eastern and includes a variety of renowned academics invited from top universities to talk about their specific research and experience.

Event Contact Information:
Alexis Newman
alexis.newman@columbia.edu

Details

Date:
March 12
Time:
11:00 am - 12:00 pm
Events Category:
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Format

Online
online
New York, NY Online United States
Phone:
08008055385
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Host

Columbia University
Phone:
212-854-1754
View Organizer Website