How Do Prefrontal Gamma Oscillations Contribute to Flexible Behavior?

Neurological Institute of NY 710 W 168th St., New York

Featuring Vikaas Sohal, MD, PhD, Assistant Professor of Psychiatry, University of California, San Francisco This seminar will be held in the Neurological Institute of New York's Auditorium (1st floor). Columbia University's Intercampus Shuttle Service is the best way to travel between campuses. Reappraising the behavioral significance of external cues is essential for many aspects of cognition. Here, I will describe published and unpublished studies using electrophysiology, optogenetics and voltage imaging to show that synchronized gamma-frequency (~40 Hz) activity, generated by parvalbumin interneurons, is critical for this process of behavioral reappraisal. These studies address a major controversy about whether synchronized patterns of neural activity, e.g., gamma oscillations, contribute to brain function in important ways or are simply epiphenomena. Deficits in parvalbumin interneurons, gamma rhythms, and behavioral reappraisal are all prominent features of schizophrenia. Thus, I will also describe how restoring parvalbumin interneuron-generated gamma rhythms may treat cognitive deficits associated with schizophrenia. Those who wish to meet the speaker during their visit should [...]

Saturday Science: Tools of the Trade

Columbia University - Jerome L. Greene Science Center 605 W. 129th St., New York

At March's Saturday Science, our theme is Tools of the Trade. Come and be curious, play and learn about the tools and technologies scientists use to study the brain. We invite families and community groups to explore the workings of the brain through hands-on activities and unique scientific resources. Our activities and demonstrations are designed to be engaging and informative, and as launching points for further exploration, reflection and discovery. Learners of all ages join scientists in the Zuckerman Institute’s Education Lab, located at 609 West 129th Street. Saturday Science events are held monthly through the school year. Themes and materials change monthly to incorporate the wide ranging topics in neuroscience and the latest discoveries coming from Zuckerman Institute labs. You have a mind to discover. Join us! This event is free and open to the public. Registration recommended. Registration information to come. Tickets are limited, so please only register if you plan on attending! If [...]