July 7-8, 2025 | Livestream, virtual training

The Quantitative Genomics Training is a two-day intensive training of seminars and hands-on analytical sessions to provide an overview of concepts, methods, and tools for whole-genome and transcriptome analyses in human health studies.

This two-day intensive workshop will provide a rigorous introduction to several different techniques to analyze whole-genome sequencing and transcriptome data. Led by a team of experts in statistical genomics and bioinformatics, who have developed their own methods to analyze such data, the training will integrate seminar lectures with hands-on computer lab sessions to put concepts into practice. The training will focus on reviewing existing approaches based on predicted expression association with traits, colocalization of causal variants, and Mendelian Randomization, including discussion on how they relate to each other, and their advantages and limitations. Emphasis will also be given to reviewing integrative sequence-based association studies for whole-genome sequencing data, and functional annotation of variants in noncoding regions of the genome.

By the end of the workshop, participants will be familiar with the following topics:

• Sequence-based association tests (Burden, SKAT and extensions)
• Functional genomic annotations
• Analysis of genomic variants in human diseases
• Transcriptome wide association tests (PrediXcan, MetaXcan, and extensions)
• Mendelian Randomization techniques
• Colocalization techniques

Audience and Requirements

Investigators at all career stages are welcome to attend, and we particularly encourage trainees and early-stage investigators to participate. There are three requirements to attend this workshop:

1. Each participant must have an introductory background in statistics and genetics, and/or in the statistical analysis of genetic data.
2. Experience using R is recommended to get the most out of lab sessions.
3. Each participant should have a laptop with R/RStudio downloaded and installed prior to the first day of training. All lab sessions will be done using Posit Cloud (formerly RStudio Cloud).

Additional Information

• Subscribe for updates on new Training details and registration deadlines. 
• Contact the Quantitative Genomics Training team.

Capacity is limited. Paid registration is required to attend.