Title: “The Human Regulome: From Comprehensive Maps to Precision Gene Control”

Speaker: John Stamatoyannopoulos, MD, Director, Altius Institute for Biomedical Sciences

In this talk I will describe recent accelerated progress toward the longstanding goal of comprehensively delineating regulatory DNA in the human genome, and its implications for understanding both the organization and evolution of the human regulome and the intersection of gene regulation with the genetics of common diseases and quantitative traits.  I will additionally discuss two novel technologies for illuminating human regulome function:  Genome-scale visualization of cis-regulatory architecture at the level of individual chromatin fibers, and nucleotide-precise in situ dissection and manipulation of transcriptional regulatory programs using synthetic DNA binding proteins.

Zoom and In-person (622 West 168th St. PH-10-405A/B). Please register to receive the Zoom link.

Refreshments will be served!